Cross Contamination – Modern Engineering Solutions to the Challenge
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Cross Contamination – Modern Engineering Solutions to the Challenge

The first references to the term “dedicated facility” appeared in GMP literature in the early 2010s in response to potential cross contamination risks of manufacturing toxicologically sensitive products in shared facilities. The WHO Technical Report Series, No. 957, 2010 ‘Annex 3 WHO good manufacturing practices for pharmaceutical products containing hazardous substances’ specifies that “production of…

United Buildings – are they a solution in times of Crisis?
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United Buildings – are they a solution in times of Crisis?

(Human) needs unquestionably shape the built environment – meaning that buildings are designed and constructed to meet people’s fundamental needs. What if these needs change suddenly for some completely unexpected reasons – such as a pandemic outbreak endangering the whole world? How will (should?) built form respond to this unexpected, sudden and significant change? The…

What are the egress requirements of a manufacturing facility?
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What are the egress requirements of a manufacturing facility?

As a multidisciplinary Architectural & Engineering team, we get asked a lot of questions relating to the application of the National Construction Code (NCC) through the design phase of (pharmaceutical) facilities in Australia. A common question relates to the provision for escape. Pharmaceutical manufacturing facilities are generally considered to have a high fire hazard potential…

Large Isolated Building, Fire Loads and Fire Compartments
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Large Isolated Building, Fire Loads and Fire Compartments

In general, pharmaceutical manufacturing facilities (usually of Class 7 and 8) tend to occupy large areas and volumes (large isolated buildings), due to the nature of the operations (such as tall process equipment availability, high capacity storage, etc.). In principle, larger spaces have higher potential fire loads. Based on this assumption, and in order to…

Building Sizing – What are the Regulatory Constraints on Building Size?
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Building Sizing – What are the Regulatory Constraints on Building Size?

Although building size will fundamentally vary depending on the production capacity of a pharmaceutical manufacturing facility, in general this type of building tends to occupy large areas and volumes due to the nature of the business (such as tall process equipment, high capacity warehouse storage, etc.). During facility design, it has always been a common…